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  • Mouse c-Met/HGFR (Fc Tag) recombinant protein

Mouse c-Met/HGFR (Fc Tag) recombinant protein

Cat.#: 503341

Special Price 342.0 USD

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Product Information

  • Product Name
    Mouse c-Met/HGFR (Fc Tag) recombinant protein
  • Documents
  • Description
    Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
  • Protein name
    Met protein
  • Protein short names
    MET; HGFR; PAR4; AI838057; RCCP2; AUTS9; C-MET; HGF
  • Uniprot ID
    F8VQL0
  • Gene Name
    Met
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse MET (NP_032617.2) extracellular domain (Met 1-Asn 929) was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse Met/Fc chimera is a disulfide-linked homodimer of the Met which is a heterodimer composed of the proteolytically cleaved ? and ? subunits. Each ? and ? together with the C-terminal Fc tag consists of 1146 amino acids and has a predicted molecular mass of 128 (? =32 + Fc tagged ?=96) kDa. The apparent molecular mass of the rm MET/Fc heterodimer thus is approximately 43 kDa and 115-120 kDa respectively in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized human HGF at 2 μg/ml (100 μl/well) can bind mouse HGFR with a linear ranger of 1.28-32ng/ml.
  • Validations

    Mouse c-MET / HGFR Protein (Fc Tag) SDS-PAGE

    Mouse c-MET / HGFR Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"