Mouse ACVR2A (His Tag) recombinant protein
ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.
Serine/threonine-protein kinase receptor
Protein short names
TACTRII; ACVR2; ACVR2A; RP23-139F8.3; ACTRII; ACTRIIA
A DNA sequence encoding the extracellular domain of mouse ACVR2A (NP_031422.3) (Met 1-Pro 134) was expressed, with a C-terminal polyhistidine tag.
The secreted recombinant mouse ACVR2A comprises 126 amino acids and has a calculated molecular mass of 14.8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 35 kDa band in SDS-PAGE under reducing conditions.
> 97 % as determined by SDS-PAGE
Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.
The ED50 for this effect is typically 0.6-3 μg/mL in the presence of 10 ng/ml Recombinant Human Activin A.
Mouse ACVR2A / ActrIIa Protein (His Tag) SDS-PAGE
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