NovoPro
Cart 2
  • Mouse ACVR2A  (His Tag) recombinant protein

Mouse ACVR2A (His Tag) recombinant protein

Cat.#: 504150

Special Price 307.5 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Mouse ACVR2A (His Tag) recombinant protein
  • Documents
  • Description
    ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.
  • Protein name
    Serine/threonine-protein kinase receptor
  • Protein short names
    TACTRII; ACVR2; ACVR2A; RP23-139F8.3; ACTRII; ACTRIIA
  • Uniprot ID
    Q8BRV4
  • Gene Name
    Acvr2a; mCG_17064
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of mouse ACVR2A (NP_031422.3) (Met 1-Pro 134) was expressed, with a C-terminal polyhistidine tag.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse ACVR2A comprises 126 amino acids and has a calculated molecular mass of 14.8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 35 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.
    The ED50 for this effect is typically 0.6-3 μg/mL in the presence of 10 ng/ml Recombinant Human Activin A.
  • Validations

    Mouse ACVR2A / ActrIIa Protein (His Tag) SDS-PAGE

    Mouse ACVR2A / ActrIIa Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"