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Product Name
Human MAPT / PHF-tau (His Tag) recombinant protein
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Description
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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Protein name
Microtubule-associated protein tau
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Protein short names
MSTD; MTBT1; AW045860; AI413597; NEUROFIBRILLARY TANGLE PROTEIN; MTBT2; PPP1R103; FTDP-17; PAIRED HELICAL FILAMENT-TAU; PPND; MTAPT; RP23-136D4.1; TAU; MAPTL; DDPAC; PHF-TAU; MICROTUBULE-ASSOCIATED PROTEIN TAU; MAPT
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Uniprot ID
P10636
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Gene Name
MAPT; MAPTL; MTBT1; TAU
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human MAPT (NP_058525.1) (Ala2-Leu352) was expressed with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human MAPT consists of 367 amino acids and predicts a molecular mass of 38.7 KDa. It migrates as an approximately 40-50 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human MAPT / Tau Protein (His Tag) SDS-PAGE
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