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  • Human CSF1R/MCSF Receptor/CD115 (His & GST Tag) recombinant protein

Human CSF1R/MCSF Receptor/CD115 (His & GST Tag) recombinant protein

Cat.#: 503099


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Product Information

  • Product Name
    Human CSF1R/MCSF Receptor/CD115 (His & GST Tag) recombinant protein
  • Documents
  • Description
    Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
  • Protein name
    Macrophage colony-stimulating factor 1 receptor
  • Protein short names
    CSFR; MGC125014; HDLS; FIM2; CSF-1-R; C-FMS; CD115; CSF1R; AI323359; M-CSF-R; FIM-2; FMS; M-CSFR; CSF-1R; CSFMR
  • Uniprot ID
  • Gene Name
    CSF1R; FMS
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CSF1R (NP_005202.2) cytoplasmic domain (Lys 543-Cys 972) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
  • Molecular weight
    The recombinant human CSF1R (aa 543-972) /GST chimera consists of 667 amino acids and has a calculated molecular mass of 76 KDa. It migrates as an approximately 75 KDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 82 % as determined by SDS-PAGE
  • Activity
    Kinase activity untested
  • Validations

    Human CSF1R / MCSF Receptor / CD115 Protein (His & GST Tag) SDS-PAGE

    Human CSF1R / MCSF Receptor / CD115 Protein (His & GST Tag) SDS-PAGE