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Product Name
Mouse LOXL2 (His Tag) recombinant protein
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Description
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 (By similarity). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
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Protein name
Lysyl oxidase homolog 2
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Protein short names
LOR2; LOXL2; WS9-14; MGC102220; 4930526G11RIK; 1110004B06RIK; 9430067E15RIK
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Uniprot ID
P58022
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Gene Name
Loxl2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Loxl2 (NP_201582.2) (Met1-Gln776) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Loxl2 consists 762 amino acids and predicts a molecular mass of 85.9 kDa.
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Purity
> (19.0+61.5)% as determined by SDS-PAGE
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Activity
Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine.
The specific activity is > 3pmoles/min/μg. -
Validations
Mouse LOXL2 / Lysyl oxidase homolog 2 Protein (His Tag)
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