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LRP2-Specific antibody

Cat.#: 112322

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Product Information

  • Product Name
    LRP2-Specific antibody
  • Documents
  • Description
    LRP2-Specific Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue. Positive FC detected in HEK-293 cells. Positive WB detected in HEK-293 cells, human brain tissue, human placenta tissue. Observed molecular weight by Western-blot: 280 kDa
  • Tested applications
    ELISA, WB, IHC, FC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    DBS antibody; Glycoprotein 330 antibody; gp330 antibody; LRP 2 antibody; LRP2 antibody; Megalin antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_004525). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IHC: 1:20-1:200

  • Validations

    HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:112322(LRP2-Specific antibody) at dilution of 1:300

    HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:112322(LRP2-Specific antibody) at dilution of 1:300

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:112322(LRP2-Specific Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:112322(LRP2-Specific Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:112322(LRP2-Specific Antibody) at dilution of 1:200 (under 40x lens).

    Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:112322(LRP2-Specific Antibody) at dilution of 1:200 (under 40x lens).

    1X10^6 HEK-293 cells were stained with 0.2ug LRP2-Specific antibody (Catalog No:112322, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.

    1X10^6 HEK-293 cells were stained with 0.2ug LRP2-Specific antibody (Catalog No:112322, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.

  • Background
    LRP2, also named as gp330 and Megalin, belongs to the LDLR family. It acts together with cubilin to mediate HDL endocytosis. LRP2 may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS). The antibody is specific to LRP2.
  • References
    • Sun C, Velazquez MA, Marfy-Smith S. Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition. Development (Cambridge, England). 141(5):1140-50. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"