Mouse IL-6 recombinant protein

Mouse IL-6 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Interleukin-6

IL6; HSF; HGF; BSF2; IFNB2; IL-6

P08505

Il6; Il-6

E. coli

A DNA sequence encoding the mouse IL6 (P08505) (Phe25-Thr211) was expressed and purified.

Mouse

The recombinant mouse IL6 consists of 188 amino acids and predicts a molecular mass of 21.9 KDa. It migrates as an approximately 22 KDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

1. Measured by its ability to bind biotinylated rat IL6ST-mFch (Cat:502123) in a functional ELISA.
2. Measured by its ability to bind biotinylated mouse IL6ST-Fc2h (Cat:501116) in a functional ELISA.
3. Measured by its ability to bind biotinylated mouse IL6ST-His (Cat:504186) in a functional ELISA.
4. Measured by its ability to bind biotinylated human IL6RB-Fch (Cat:501833) in a functional ELISA.
5. Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED₅₀ for this effect is typically 0.4-2 ng/ml.