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Human IL5RA (CD125) (His Tag) recombinant protein

Cat.#: 502140

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Product Information

  • Product Name
    Human IL5RA (CD125) (His Tag) recombinant protein
  • Documents
  • Description
    This is the receptor for interleukin-5. The alpha chain binds to IL5.
  • Protein name
    Interleukin-5 receptor subunit alpha
  • Protein short names
    IL5R; HSIL5R3; CD125; CDW125; MGC26560; IL5RA
  • Uniprot ID
    Q01344
  • Gene Name
    IL5RA; IL5R
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human IL5Ra isoform 2 (Q01344-2) (Met 1-Arg 335) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IL5Ra consists of 326 amino acids after removal of the signal peptide and has a predicted molecular mass of 37.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhIL5Ra is approximately 45-50 kDa due to glycosylation.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    1. Measured by its binding ability in a functional ELISA.
    2. Immobilized recombinant mouse IL5-his at 5 μg/mL (100 μL/well) can bind biotinylated human IL5Ra-his with a linear range of 32-4000 ng/mL.
    3. Measured by its ability to inhibit IL5 dependent proliferation of TF1 human erythroleukemic cells. The ED50 for this effect is typically 0.7-2.8 μg/mL.
  • Validations

    Human IL5Ra / CD125 Protein (His Tag) SDS-PAGE

    Human IL5Ra / CD125 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"