Human IL-4/IL4 / Interleukin-4 recombinant protein

Human IL-4/IL4 / Interleukin-4 recombinant protein

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• Material Safety Data Sheets (MSDS)

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

Interleukin-4

BCGF-1; BSF1; RP23-188H3.4; BSF-1; MGC79402; IL-4; BCGF1; IL4

P05112

IL4

E. coli

A DNA sequence encoding the mature form of human IL4 isoform 1 (P05112-1) (His 25-Ser 153) was expressed and purified, with an initial Met.

Human

The recombinant human IL4 consisting of 130 amino acids and migrates with an apparent molecular mass of 15 kDa as predicted.

> 92 % as determined by SDS-PAGE

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 0.05-0.2 ng/mL.
The specific activity of Recombinant Human IL-4 is approximately 3.2 × 10⁴ IU/μg