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Mouse IL-1 alpha / IL-1F1 / IL1A recombinant protein

Cat.#: 501499

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Special Price 244.8 USD

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Product Information

  • Product Name
    Mouse IL-1 alpha / IL-1F1 / IL1A recombinant protein
  • Documents
  • Description
    Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
  • Protein name
    Interleukin-1 alpha
  • Protein short names
    IL-1A; IL1F1; IL1A; IL1-ALPHA; IL1; IL-1 ALPHA
  • Uniprot ID
    Q3U0Y6
  • Gene Name
    Il1a
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of mouse IL1A (NP_034684.2) (Ser 115-Ser 270) was expressed, with an initial Met at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse IL1A consists of 157 amino acids and migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions as predicted.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Activity
    1. Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is typically 2-10 pg/mL.
    2. Measured by its binding ability in a functional ELISA.
    3. Immobilized mouse IL1A at 10 μg/mL (100 μl/well) can bind mouse IL1R1, The EC50 of mouse IL1R1 is 0.13 μg/mL.
  • Validations

    Mouse IL-1 alpha / IL1A / IL1F1 Protein SDS-PAGE

    Mouse IL-1 alpha / IL1A / IL1F1 Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"