Human ICOS/AILIM/CD278 (His & Fc Tag) recombinant protein

Cat.#: 501450

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Product Information

  • Product Name
    Human ICOS/AILIM/CD278 (His & Fc Tag) recombinant protein
  • Documents
  • Description
    Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.
  • Protein name
    Inducible T-cell co-stimulator
  • Protein short names
    LY115; ICOS; AILIM; H4; CVID1; MGC39850; CD278; CH29-120A16.4; CRP-1; CCLP
  • Uniprot ID
    Q9Y6W8
  • Gene Name
    ICOS; hCG_1642889
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of human ICOS (NP_036224.1) (Met 1-Phe 141) was fused to the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human ICOS/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 368 amino acids and predicts a molecular mass of 41.6 kDa. The apparent molecular mass of rhICOS/Fc monomer is approximately 50 kDa due to glycosylation.
  • Purity
    > 94 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized human human B7-H2 at 1 μg/ml (100 μl/well) can bind human ICOS with a linear range of 1.6-200 ng/ml.
  • Validations

    Human ICOS / AILIM / CD278 Protein (His & Fc Tag) SDS-PAGE

    Human ICOS / AILIM / CD278 Protein (His & Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"