IDR1018 peptide

IDR1018 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

1 Vial

H-VRLIVAVRIWRR-NH2

H-Val-Arg-Leu-Ile-Val-Ala-Val-Arg-Ile-Trp-Arg-Arg-NH2

12

95.3%

C₇₁H₁₂₆N₂₆O₁₂

1535.92

Synthetic

Peptide IDR-1018 is a 12-amino acid anti-biofilm peptide. When stimulated, it induces the degradation of the second signaling molecule (p) ppGpp, causing the destruction of biofilm integrity and leading to the degradation of mature biofilms. Peptide IDR-1018 is often used in combination with antimicrobial peptides to achieve antibacterial effects.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Etayash H, Yip F, Hancock REW. Impacts of PEGylation and Glycosylation on the Biological Properties of Host Defense Peptide IDR1018. Pharmaceutics. 2023 May 1;15(5):1391. doi: 10.3390/pharmaceutics15051391. PMID: 37242633; PMCID: PMC10223877.

Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

TFA Removal Service is recommended for:

• Peptides that will be used in cellular assays
• Peptides that will be used as APIs or in manufactured products
• For hydrophilic peptides containing numerous basic residues