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Product Name
Human UBE2G2 (GST tag) recombinant protein
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Description
Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s.
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Protein name
ubiquitin conjugating enzyme E2 G2(UBE2G2)
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Uniprot ID
P60604
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human UBE2G2 Met1-Leu165 is expressed with a GST tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human UBE2G2 (GST tag) recombinant protein
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