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Product Name
Human TNFRSF18/AITR/GITR/UNQ319/PRO364 (Fc tag) recombinant protein
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Description
Glucocorticoid-induced tumor necrosis factor receptor (GITR) is type I transmembrane protein belonging to the TNF R family. It contains 3 TNFR-Cys repeats and it have four isforms: IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. GITR seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway. It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA. It is preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
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Protein name
TNF receptor superfamily member 18(TNFRSF18)
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Protein short names
AITR; GITR; UNQ319; PRO364
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Uniprot ID
Q9Y5U5
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human TNFRSF18/AITR/GITR/UNQ319/PRO364 Gln26-Gln161 is expressed with a Fc tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human TNFRSF18/AITR/GITR/UNQ319/PRO364 (Fc tag) recombinant protein
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