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Product Name
Human S100A8/S100A9 Heterodimer (His tag) recombinant protein
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Description
S100A8 is a member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. Calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.
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Protein name
S100 Calcium Binding Protein A8/A9 Heterodimer
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Protein short names
S100A9 Heterodimer
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Uniprot ID
P05109 & P06702
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human S100A8/S100A9 Heterodimer Met1-Glu93(S100A8)&Thr2-Pro114(S100A9) is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human S100A8/S100A9 Heterodimer (His tag) recombinant protein
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