Human RET (His Tag) recombinant protein

Cat.#: 503548

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Product Information

  • Product Name
    Human RET (His Tag) recombinant protein
  • Documents
  • Description
    RET proto-oncogene, also known as RET, is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the protein kinase superfamily, tyr protein kinase family. RET proto-oncogene is involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. It phosphorylates PTK2/FAK1 and regulates both cell death/survival balance and positional information. RET is required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life; promotes the formation of Peyer's patch-like structures; modulates cell adhesion via its cleavage; involved in the development of the neural crest. RET proto-oncogene is active in the absence of ligand, triggering apoptosis. RET acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. It also regulates nociceptor survival and size; triggers the differentiation of rapidly adapting (RA) mechanoreceptors; mediated several diseases such as neuroendocrine cancers. Defects in RET may cause colorectal cancer, hirschsprung disease type 1, medullary thyroid carcinoma, multiple neoplasia type 2B, susceptibility to pheochromocytoma, multiple neoplasia type 2A, thyroid papillary carcinoma and congenital central hypoventilation syndrome.
  • Protein name
    Proto-oncogene tyrosine-protein kinase receptor Ret
  • Protein short names
    RET9; RET51; PTC; MEN2B; MTC1; RET-ELE1; RET; CDHF12; C-RET; MEN2A; HSCR1; CDHR16
  • Uniprot ID
    P07949
  • Gene Name
    RET; CDHF12; CDHR16; PTC; RET51
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of human RET (P07949-1) (Met 1-Arg 635) was fused with a polyhistidine tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human RET consists of 618 amino acids and has a calculated molecular mass of 69.1 kDa. The apparent molecular mass of the protein is approximately 110-120 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Validations

    Human RET Kinase Protein (His Tag) SDS-PAGE

    Human RET Kinase Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"