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  • Human PPM1A/PPPM1A (His tag) recombinant protein

Human PPM1A/PPPM1A (His tag) recombinant protein

Cat.#: 519832

Special Price 229.9 USD

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Product Information

  • Product Name
    Human PPM1A/PPPM1A (His tag) recombinant protein
  • Documents
  • Description
    Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also, it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition, PPM1A can dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.
  • Protein name
    protein phosphatase, Mg2+/Mn2+ dependent 1A(PPM1A)
  • Protein short names
    PPPM1A
  • Uniprot ID
    P35813
  • Source/Expression Host
    E.coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human PPM1A/PPPM1A Gly2-Trp382 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human PPM1A/PPPM1A (His tag) recombinant protein

    Human PPM1A/PPPM1A (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"