Human PPARG Recombinant protein (GST tag)

Human PPARG Recombinant protein (GST tag)

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Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

Peroxisome proliferator-activated receptor gamma

PPAR-GAMMA; PPARGAMMA; PPARG2; PPARG1; NR1C3; PPAR-GAMMA2; CIMT1; GLM1; PPARGAMMA2

P37231

PPARG; NR1C3

E. coli

1-111 aa encoded by XM_011533841 was inserted into PGEX-4T vector

Human

Not tested.