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Product Name
Human PINX1/LPTL/LPTS (His tag) recombinant protein
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Description
PIN2/TERF1-Interacting Telomerase Inhibitor 1 (PINX1) belongs to the PINX1 family . PINX1 contains a G-patch domain and a Telomerase Inhibiting Domain that is capable of binding MCRS1, TERT and TERF1. PINX1 is a widely expressed protein that localizes to nucleoli and telomere speckles. PINX1 can mediate TRF1 and TERT accumulation in nucleolus and enhance TRF1 binding to telomeres. PINX1 is recruited to chromosome periphery by Nucleolin, the complex is necessary for faithful chromosome congression. In addition, PINX1 may inhibit cell proliferation and act as tumor suppressor.
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Protein name
PIN2/TERF1 interacting, telomerase inhibitor 1(PINX1)
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Protein short names
LPTL; LPTS
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Uniprot ID
Q96BK5
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human PINX1/LPTL/LPTS Met1-Lys328 is expressed with a 6His tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human PINX1/LPTL/LPTS (His tag) recombinant protein
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