NovoPro
Cart 2
  • Human PD-1/CD279 Recombinant protein (His tag)

Human PD-1/CD279 Recombinant protein (His tag)

Cat.#: 511039

Size:

Special Price 0.0 USD

Availability: Discontinued
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human PD-1/CD279 Recombinant protein (His tag)
  • Documents
  • Description
    Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
  • Protein name
    Programmed cell death protein 1
  • Protein short names
    SLEB2; LY101; PDCD1; CD279; HPD-1; PDC1; HPD-L; PD-1; PD1
  • Uniprot ID
    Q15116
  • Gene Name
    PDCD1; PD1
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    1-288 aa encoded by BC074740 was inserted into PET28a vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human PD-1/CD279 SDS-PAGE

    Recombinant human PD-1/CD279 SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"