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  • Human PCNA Recombinant protein (GST tag)

Human PCNA Recombinant protein (GST tag)

Cat.#: 510983

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Product Information

  • Product Name
    Human PCNA Recombinant protein (GST tag)
  • Documents
  • Description
    Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
  • Protein name
    Proliferating cell nuclear antigen
  • Protein short names
    RP23-33N15.1; MGC8367; ATLD2
  • Uniprot ID
    P12004
  • Gene Name
    PCNA
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    8-256 aa encoded by BC000491 was inserted into PGEX-4T vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human PCNA SDS-PAGE

    Recombinant human PCNA SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"