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  • Human PAPSS1/ATPSK1/PAPSS (His tag) recombinant protein

Human PAPSS1/ATPSK1/PAPSS (His tag) recombinant protein

Cat.#: 519361

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Product Information

  • Product Name
    Human PAPSS1/ATPSK1/PAPSS (His tag) recombinant protein
  • Documents
  • Description
    PAPSS1 is a bifunctional enzyme with both ATP sulfurylase and APS kinase activity. In the N-terminal section, it belongs to the APS kinase family; while the C-terminal section belongs to the sulfate adenylyltransferase family. PAPSS1 can be inhibited by chlorate, and is expressed in many tissues, such as high endothelial venules (HEV) cells and in cartilage. PAPSS1 mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate. In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. PAPSS1 also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
  • Protein name
    3'-phosphoadenosine 5'-phosphosulfate synthase 1(PAPSS1)
  • Protein short names
    ATPSK1; PAPSS
  • Uniprot ID
    O43252
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human PAPSS1/ATPSK1/PAPSS Met1-Ala624 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human PAPSS1/ATPSK1/PAPSS (His tag) recombinant protein

    Human PAPSS1/ATPSK1/PAPSS (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"