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Product Name
Human NRG1 (His Tag) recombinant protein
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Description
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
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Protein name
Pro-neuregulin-1, membrane-bound isoform
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Protein short names
MSTP131; HRG1; NDF; HGL; GGF; ARIA; MST131; HRGALPHA; HRGA; D230005F13RIK; NRG1-IT2; 6030402G23RIK; GGF2; SMDF; GGFII; HRG
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Uniprot ID
Q6PK61
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Gene Name
NRG1; GGF; HGL; HRGA; NDF; SMDF
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human NRG1 (NP_001153480.1) (Ser20-Lys238) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human NRG1 consists 230 amino acids and predicts a molecular mass of 25.3 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Human NRG1 Protein (His Tag)
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