Human NRG1 (Fc Tag) recombinant protein

Cat.#: 504102

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Product Information

  • Product Name
    Human NRG1 (Fc Tag) recombinant protein
  • Documents
  • Description
    Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. 
  • Protein name
    Pro-neuregulin-1, membrane-bound isoform
  • Protein short names
    6030402G23RIK; GGF2; D230005F13RIK; HRGALPHA; HRGA; ARIA; HGL; NDF; HRG; NRG1-IT2; GGFII; SMDF; MST131; GGF; MSTP131; HRG1
  • Uniprot ID
    Q02297
  • Gene Name
    NRG1; GGF; HGL; HRGA; NDF; SMDF
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was expressed, fused with the Fc region of mouse IgG1 at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human NRG1/mFc is a disulfide-linked homodimer. The reduced monomer comprises 481 amino acids and has a predicted molecular mass of 53.4 kDa. The apparent molecular mass of the monomer is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 88 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind with human ErbB4-His (Cat:503994) in a functional ELISA.
    2. Measured by its ability to bind with human ErbB3-His (Cat:503568) in a functional ELISA.
  • Validations

    Human NRG1-beta 1 Protein (Fc Tag) SDS-PAGE

    Human NRG1-beta 1 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"