Human NCR3LG1/B7H6 (His tag) recombinant protein

Human NCR3LG1/B7H6 (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Natural cytotoxicity triggering receptor 3 ligand 1(B7-H6) is a glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H6 consists of a 238 amino acid (aa) extracellular domain (ECD) that contains one Ig-like V domain and one Ig-like C1 domain, a 21 aa transmembrane segment, and a 171 aa cytoplasmic domain that contains one ITIM, one SH2, and one SH3 motif. Both of the Ig-like domains carry N-linked glycosylation. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors.

natural killer cell cytotoxicity receptor 3 ligand 1(NCR3LG1)

B7H6

Q68D85

Human Cells

A DNA sequence encoding the Human NCR3LG1/B7H6 Asp25-Ser262 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.