Human MPZ (His tag) recombinant protein

Human MPZ (His tag) recombinant protein

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Myelin Protein P0 (MPZ) is a single-pass type I membrane glycoprotein which belongs to the myelin P0 protein family. MPZ contains one Ig-like V-type (immunoglobulin-like) domain, absent in the central nervous system. MPZ is a major component of the myelin sheath in peripheral nerves. It is postulated that MPZ is a structural element in the formation and stabilisation of peripheral nerve myelin, holding its characteristic coil structure together by the interaction of its positively-charged domain with acidic lipids in the cytoplasmic face of the opposed bilayer, and by interaction between hydrophobic globular of adjacent extracellular domains. Defects in MPZ associated with Charcot-Marie-Tooth disease and Dejerine-Sottas disease.

myelin protein zero(MPZ)

P25189

Human Cells

A DNA sequence encoding the Human MPZ Ile30-Arg153 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.