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  • Human METAP2/MNPEP/P67EIF2 (His tag) recombinant protein

Human METAP2/MNPEP/P67EIF2 (His tag) recombinant protein

Cat.#: 518041

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Product Information

  • Product Name
    Human METAP2/MNPEP/P67EIF2 (His tag) recombinant protein
  • Documents
  • Description
    Human Methionine Aminopeptidase 2 (METAP2, MAP2) is a member of the M24 family of metalloproteases. METAPs catalyze the removal of the initiator methionine residue from nascent peptides and are essential for cell growth. MAP2 binds 2 cobalt or manganese ions and contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. It is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation. METAP2 plays an important role in the development of different types of cancer and has been a novel target for developing anti-cancer drugs. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amno-terminal methionine residue from nascent protein. MAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. It also plays a critical role in the regulation of protein synthesis.
  • Protein name
    methionyl aminopeptidase 2(METAP2)
  • Protein short names
    MNPEP; P67EIF2
  • Uniprot ID
    P50579
  • Source/Expression Host
    E.coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human METAP2/MNPEP/P67EIF2 Ala2-Tyr478 is expressed with a 6His tag at the N-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human METAP2/MNPEP/P67EIF2 (His tag) recombinant protein

    Human METAP2/MNPEP/P67EIF2 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"