Human M-CSF/CSF-1 (His Tag) recombinant protein

Cat.#: 503408

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Product Information

  • Product Name
    Human M-CSF/CSF-1 (His Tag) recombinant protein
  • Documents
  • Description
    Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.
  • Protein name
    Macrophage colony-stimulating factor 1
  • Protein short names
    C87615; OP; CSFM; CSF-1; RP11-195M16.2; CSF1; M-CSF; MGC31930; MCSF
  • Uniprot ID
    P09603
  • Gene Name
    CSF1
  • Source/Expression Host
    Yeast
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CSF1 (NP_757349.1) (Glu33-Asn190) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CSF1 consists 168 amino acids and predicts a molecular mass of 19.8 kDa.
  • Purity
    > (45.8+27.8+25.7) % as determined by SDS-PAGE.
  • Activity
    Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells.
    The ED50 for this effect is typically 1-4 ng/mL.
  • Validations

    Human M-CSF / CSF-1 Protein (His Tag) SDS-PAGE

    Human M-CSF / CSF-1 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"