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  • Human LILRB2/ILT4/LIR2/MIR10 (His tag) recombinant protein

Human LILRB2/ILT4/LIR2/MIR10 (His tag) recombinant protein

Cat.#: 519592

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Product Information

  • Product Name
    Human LILRB2/ILT4/LIR2/MIR10 (His tag) recombinant protein
  • Documents
  • Description
    Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
  • Protein name
    leukocyte immunoglobulin like receptor B2(LILRB2)
  • Protein short names
    ILT4; LIR2; MIR10
  • Uniprot ID
    Q8N423
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human LILRB2/ILT4/LIR2/MIR10 Gln22-His458 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human LILRB2/ILT4/LIR2/MIR10 (His tag) recombinant protein

    Human LILRB2/ILT4/LIR2/MIR10 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"