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  • Human LCK Recombinant protein (His tag)

Human LCK Recombinant protein (His tag)

Cat.#: 509431

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Product Information

  • Product Name
    Human LCK Recombinant protein (His tag)
  • Documents
  • Description
    Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP.
  • Protein name
    Tyrosine-protein kinase Lck
  • Protein short names
    YT16; PP58LCK; HCK-3; RP23-209C6.8; RP4-675E8.4; LCK; IMD22; P56LCK; LSKT; LSK; LCK> P56<
  • Uniprot ID
    P06239
  • Gene Name
    LCK
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    236-539 aa encoded by BC013200 was inserted into PET28a vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human LCK SDS-PAGE

    Recombinant human LCK SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"