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Product Name
Human IL6 recombinant protein (Native)
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Description
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
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Protein name
cDNA FLJ61423, highly similar to Interleukin-6
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Protein short names
BSF2,HGF,HSF,IFNB2,IL-6,Interleukin-6
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Uniprot ID
B4DVM1
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Gene Name
cDNA FLJ61423, highly similar to Interleukin-6
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human IL6 (NP_000591.1) (Val30-Met212) was expressed with an initial Met at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IL6 consists of 184 amino acids and has a calculated molecular mass of 20.9 kDa.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human IL6/IL-6/Interleukin-6 Protein 14107
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"