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Product Name
Human IL1B recombinant protein (Native)
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Description
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
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Protein name
Interleukin-1 beta
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Protein short names
IL-1,IL-1 beta,IL-1B,IL1-BETA,IL1F2
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Uniprot ID
P01584
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Gene Name
Interleukin-1 beta; IL-1 beta; Catabolin
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human IL1B (NP_000567.1) (Ala 117-Ser 269) was expressed with a N-terminal Met.
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Protein Species
Human
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Molecular weight
The recombinant human IL1B consists of 154 amino acids and predicts a molecular mass of 17.5 kDa
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Human IL1B/IL-1B/IL-1 beta Protein 14962
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