Human IL17A/CTLA8/IL17 (His tag) recombinant protein

Human IL17A/CTLA8/IL17 (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

interleukin 17A(IL17A)

CTLA8; IL17

Q16552

Human Cells

A DNA sequence encoding the Human IL17A/CTLA8/IL17 Gly24-Ala155 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.