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  • Human IL-8/CXCL8 (aa 28-99) recombinant protein

Human IL-8/CXCL8 (aa 28-99) recombinant protein

Cat.#: 504282

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Product Information

  • Product Name
    Human IL-8/CXCL8 (aa 28-99) recombinant protein
  • Documents
  • Description
    Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Interleukin (IL)-8/CXCL8 is a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. However, several lines of evidence indicate that IL-8/CXCL8 has a wide range of actions on various types of cells, including lymphocytes, monocytes, endothelial cells, and fibroblasts, besides neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression.
  • Protein name
    C-X-C motif chemokine
  • Uniprot ID
    P10145
  • Gene Name
    IL8; hCG_16372
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    The 72 amino acid residue form (Ser 28-Ser 99) of mature human IL8 (NP_000575.1) was expressed and purified.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human cytokine IL8 isoform comprising 72 amino acids predicts a molecular mass of 8.5 kDa, and migrates as an approximately 12 kDa protein in SDS-PAGE.due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human IL-8 / CXCL8 Protein (aa 6-77) SDS-PAGE

    Human IL-8 / CXCL8 Protein (aa 6-77) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"