Human IL-3 recombinant protein

Human IL-3 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

IL3 (interleukin 3), also known as IL-3, is a potent growth promoting cytokine which belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells. IL3/IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

Interleukin-3

IL-3; IL3; BPA; MGC79399; HCGF; PSF; RP23-309E16.5; CSFMU; MGC79398; MULTI-CSF; MCGF

P08700

IL3

E. coli

A DNA sequence encoding the human IL3 (NP_000579.2) (Ala20-Phe152) was expressed with an initial Met.

Human

The recombinant human IL3 consists 134 amino acids and predicts a molecular mass of 15.2 kDa.

> 95 % as determined by SDS-PAGE.

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
The ED₅₀ for this effect is typically 0.04-0.2 ng/mL.