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  • Human HBEGF/DTR/DTS/HEGFL (His tag) recombinant protein

Human HBEGF/DTR/DTS/HEGFL (His tag) recombinant protein

Cat.#: 519284

Special Price 121.9 USD

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Product Information

  • Product Name
    Human HBEGF/DTR/DTS/HEGFL (His tag) recombinant protein
  • Documents
  • Description
    Heparin-binding EGF-like growth factor (HB-EGF) is a 12­16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF­like domain, and a heparin-binding motif. Mature HB­EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB­EGF shows 76% and 73% aa sequence identity with rat and mouse HB­EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB­EGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non­mitogenic actions, while EGFR binding induces both mitogenic and non­mitogenic activity.
  • Protein name
    heparin binding EGF like growth factor(HBEGF)
  • Protein short names
    DTR; DTS; HEGFL
  • Uniprot ID
    Q99075
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human HBEGF/DTR/DTS/HEGFL Leu20-Leu148 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human HBEGF/DTR/DTS/HEGFL (His tag) recombinant protein

    Human HBEGF/DTR/DTS/HEGFL (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"