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  • Human FCAR/CD89 (His tag) recombinant protein

Human FCAR/CD89 (His tag) recombinant protein

Cat.#: 519834

Special Price 233.2 USD

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Product Information

  • Product Name
    Human FCAR/CD89 (His tag) recombinant protein
  • Documents
  • Description
    Immunoglobulin α Fc Receptor (IgA Fc Receptor) is a member of the immunoglobulin gene superfamily. It is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens through the charged arginin residue within its transmembrane domain. IgA Fc Receptor binds both IgA1 and IgA2 with similar affinity. The site of interaction between FCAR and IgA was identified in the first extracellular domain of FCAR and the C2/C3 junction of IgA. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is also expressed on Kupffer cells in the liver, where it was suggested to provide a second line of defense.
  • Protein name
    Fc fragment of IgA receptor(FCAR)
  • Protein short names
    CD89
  • Uniprot ID
    P24071
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human FCAR/CD89 Gln22-Asn227 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human FCAR/CD89 (His tag) recombinant protein

    Human FCAR/CD89 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"