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  • Human DKK2/UNQ682/PRO1316 (Fc & His tag) recombinant protein

Human DKK2/UNQ682/PRO1316 (Fc & His tag) recombinant protein

Cat.#: 518669

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Product Information

  • Product Name
    Human DKK2/UNQ682/PRO1316 (Fc & His tag) recombinant protein
  • Documents
  • Description
    Dickkopf-related protein 2 (DKK2), is a member of the dickkopf family. DKK2 is secreted protein which contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • Protein name
    dickkopf WNT signaling pathway inhibitor 2(DKK2)
  • Protein short names
    UNQ682; PRO1316
  • Uniprot ID
    Q9UBU2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human DKK2/UNQ682/PRO1316 Asp251-Ile526 is expressed with a Fc tag at the N-terminus, 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human DKK2/UNQ682/PRO1316 (Fc & His tag) recombinant protein

    Human DKK2/UNQ682/PRO1316 (Fc & His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"