Human DKK2/UNQ682/PRO1316 (Fc & His tag) recombinant protein

Human DKK2/UNQ682/PRO1316 (Fc & His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Dickkopf-related protein 2 (DKK2), is a member of the dickkopf family. DKK2 is secreted protein which contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

dickkopf WNT signaling pathway inhibitor 2(DKK2)

UNQ682; PRO1316

Q9UBU2

Human Cells

A DNA sequence encoding the Human DKK2/UNQ682/PRO1316 Asp251-Ile526 is expressed with a Fc tag at the N-terminus, 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.