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  • Human DKK1/UNQ492/PRO1008 (His tag) recombinant protein

Human DKK1/UNQ492/PRO1008 (His tag) recombinant protein

Cat.#: 519283

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Product Information

  • Product Name
    Human DKK1/UNQ492/PRO1008 (His tag) recombinant protein
  • Documents
  • Description
    Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • Protein name
    dickkopf WNT signaling pathway inhibitor 1(DKK1)
  • Protein short names
    UNQ492; PRO1008
  • Uniprot ID
    O94907
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human DKK1/UNQ492/PRO1008 Thr32-His266 is expressed with a 8His tag at the N-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human DKK1/UNQ492/PRO1008 (His tag) recombinant protein

    Human DKK1/UNQ492/PRO1008 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"