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  • Human CDK5 (GST Tag) recombinant protein

Human CDK5 (GST Tag) recombinant protein

Cat.#: 501780

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Product Information

  • Product Name
    Human CDK5 (GST Tag) recombinant protein
  • Documents
  • Description
    Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2 / CDKX subfamily. Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was joined by CDK5, which is an atypical member in that it uses its own activators and is multifunctional, playing important regulatory roles in multiple cellular functions. CDK5, unlike other Cdks, is not regulated by cyclins, and its activity is primarily detected in postmitotic neurons in developing and adult nervous systems. CDK5 is activated by association with a neuron-specific activator, p35 or its isoform p39. CDK5 is probably involved in the control of the cell cycle. It interacts with D1 and D3-type G1 cyclins. CDK5 can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. It also interacts with p35 which activates the kinase. CDK5 plays important roles in various neuronal activities, including neuronal migration, synaptic activity, and neuronal cell death.
  • Protein short names
    CRK6; AW048668; PSSALRE; CDK5
  • Uniprot ID
    Q00535
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CDK5 isoform 1 (NP_004926.1) (Met 1-Pro 292) was fused with the GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CDK5/GST chimera consists of 516 amino acids and has a predicted molecular mass of 59.6 kDa as estimated in SDS-PAGE under reducing conditions.
  • Purity
    > 94 % as determined by SDS-PAGE
  • Activity
    No Kinase Activity
  • Validations

    Human CDK5 Protein (GST Tag) SDS-PAGE

    Human CDK5 Protein (GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"