Human CD40/TNFRSF5 (Fc Tag) recombinant protein

Human CD40/TNFRSF5 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Tumor necrosis factor receptor superfamily member 5

IGM; T-BAM; BP50; CD40; HIGM1; TNFRSF5; CDW40; IMD3; AI326936; P50; GP39; MGC9013; RP23-428M13.1; TRAP

Q6P2H9

CD40; TNFRSF5

Human Cells

A DNA sequence encoding the human CD40 (NP_001241.1) (Met1-Arg193) was expressed with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human CD40 consists 414 amino acids and predicts a molecular mass of 46.2 kDa.

> 90 % as determined by SDS-PAGE.

1. Measured by its binding ability in a functional ELISA.
2. Immobilized human CD40L-His (Cat:504291) at 10 μg/mL (100 μL/well) can bind Human CD40-Fc. The EC₅₀ of Human CD40-Fc is 4-10 ng/mL.