Human CD28 (Fc tag) recombinant protein

Cat.#: 519048

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Product Information

  • Product Name
    Human CD28 (Fc tag) recombinant protein
  • Documents
  • Description
    T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
  • Protein name
    CD28 molecule(CD28)
  • Uniprot ID
    P10747
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human CD28 Asn19-Pro152 is expressed with a Fc tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human CD28 (Fc tag) recombinant protein

    Human CD28 (Fc tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"