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  • Human c-Met/HGFR (His Tag) recombinant protein

Human c-Met/HGFR (His Tag) recombinant protein

Cat.#: 504042

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Product Information

  • Product Name
    Human c-Met/HGFR (His Tag) recombinant protein
  • Documents
  • Description
    Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
  • Protein short names
    RCCP2; C-MET; AUTS9; HGF; HGFR; MET; AI838057; PAR4
  • Uniprot ID
    P08581
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of human c-Met (NP_000236) (Met 1-Thr 932) was fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The mature form of recombinant human c-Met is a disulfide-linked heterodimer composed of proteolytically cleaved ? and ? subunits. Each ? and ? subunit together consists of 919 amino acids and has a predicted molecular mass of 103 (?=33 +?=70) kDa. As a result of glycosylation, rh c-MET heterodimer thus migrates with apparent molecular mass of approximately 45 kDa and 85 kDa respectively in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized recombinant human HGF at 10 μg/ml (100 μl/well) can bind biotinylated c-Met. The EC50 of biotinylated c-Met is 5.28 μg/ml.
  • Validations

    Human c-MET / HGFR Protein (His Tag) SDS-PAGE

    Human c-MET / HGFR Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"