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  • Human BTN3A1 recombinant protein (C-cleavage)

Human BTN3A1 recombinant protein (C-cleavage)

Cat.#: 514773

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Product Information

  • Product Name
    Human BTN3A1 recombinant protein (C-cleavage)
  • Documents
  • Description
    BTN3A1 has the structure of a type I receptor of the Ig superfamily and is part of a family of seven BTN receptors encoded by genes in the MHC. BTN molecules are composed of two Ig domains (IgV, IgC2), a single transmembrane domain, and a large carboxyl-terminal domain termed B30.2 (or PRYSPRY) located in the cell cytoplasm. There are three human BTN3A loci, BTN3A1, BTN3A2, and BTN3A3, and clear orthologs of BTN3A molecules, now called CD277, are absent from the mouse genome. Despite its similarity to B7 molecules, BTN3A1 was proposed to act not as a coreceptor or costimulatory molecule, but rather to directly present pAg to the γδ TCR in a manner analogous to MHC-restricted peptide presentation. However, this model of BTN3A1 function has been challenged by conflicting data, which show pAg binding to a positively charged pocket in the cytosolic B30.2 domain, and that BTN3A1 does not directly engage the γδ TCR. This contradictory picture has emerged as a result of the complexity of the system and in particular by the use of endogenous and exogenous routes of Ag delivery in in vitro assays.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
  • Protein name
    cDNA FLJ77123, highly similar to Homo sapiens butyrophilin, subfamily 3, member A1
  • Protein short names
    BT3.1,BTF5,BTN3.1,CD277
  • Uniprot ID
    A8K547
  • Gene Name
    cDNA FLJ77123, highly similar to Homo sapiens butyrophilin, subfamily 3, member A1; BTN3A1, transcript variant 2, mRNA
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human BTN3A1 (NP_919423.1) (Met1-Gly254) was expressed with five amino acids (DDDDK) at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human BTN3A1 consists of 231 amino acids and predicts a molecular mass of 24.8 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Human BTN3A1 / CD277 Protein 14489

    Human BTN3A1 / CD277 Protein 14489

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"