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  • Human BLNK/BASH/SLP65 (His tag) recombinant protein

Human BLNK/BASH/SLP65 (His tag) recombinant protein

Cat.#: 518180

Special Price 156.8 USD

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Product Information

  • Product Name
    Human BLNK/BASH/SLP65 (His tag) recombinant protein
  • Documents
  • Description
    B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain. BLNK is expressed in B cells and fibroblast cell lines, playing a important role in B cell receptor signaling. BLNK as a central linker protein, downstream of the B-cell receptor (BCR), bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. BLNK associates with the activation of ERK/EPHB2, MAP kinase p38 and JNK, modulates AP1, NF-kappa-B and NFAT activation. BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development.
  • Protein name
    B-cell linker(BLNK)
  • Protein short names
    BASH; SLP65
  • Uniprot ID
    Q8WV28
  • Source/Expression Host
    E.coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human BLNK/BASH/SLP65 Met1-Ser456 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human BLNK/BASH/SLP65 (His tag) recombinant protein

    Human BLNK/BASH/SLP65 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"