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Product Name
Human BLNK/BASH/SLP65 (His tag) recombinant protein
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Description
B-Cell Linker Protein (BLNK) is a cell membrane protein which contains 1 SH2 domain. BLNK is expressed in B cells and fibroblast cell lines, playing a important role in B cell receptor signaling. BLNK as a central linker protein, downstream of the B-cell receptor (BCR), bridges the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. BLNK associates with the activation of ERK/EPHB2, MAP kinase p38 and JNK, modulates AP1, NF-kappa-B and NFAT activation. BLNK involves in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK deficiency results in agammaglobulinemia type 4 and much more profound block in B-cell development.
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Protein name
B-cell linker(BLNK)
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Protein short names
BASH; SLP65
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Uniprot ID
Q8WV28
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human BLNK/BASH/SLP65 Met1-Ser456 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human BLNK/BASH/SLP65 (His tag) recombinant protein
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