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  • Human B2M/CDABP0092/HDCMA22P (His tag) recombinant protein

Human B2M/CDABP0092/HDCMA22P (His tag) recombinant protein

Cat.#: 519758

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Product Information

  • Product Name
    Human B2M/CDABP0092/HDCMA22P (His tag) recombinant protein
  • Documents
  • Description
    β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.
  • Protein name
    beta-2-microglobulin(B2M)
  • Protein short names
    CDABP0092; HDCMA22P
  • Uniprot ID
    P61769
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human B2M/CDABP0092/HDCMA22P Ile21-Met119 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human B2M/CDABP0092/HDCMA22P (His tag) recombinant protein

    Human B2M/CDABP0092/HDCMA22P (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"