Human ACVR2A (His Tag) recombinant protein

Human ACVR2A (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.

Activin receptor type-2A

RP23-139F8.3; ACTRIIA; ACTRII; TACTRII; ACVR2; ACVR2A

P27037

ACVR2A; ACVR2

Human Cells

A DNA sequence encoding the extracellular domain of human ACVR2A (NP_001607.1) (Met 1-Pro 134) was expressed, with a polyhistidine tag at the C-terminus.

Human

The recombinant human ACVR2A comprises 126 amino acids and predicts a molecular mass of 14.9 kDa. As a result of glycosylation, the apparent molecular mass of the protein is approximately 35-40 kDa in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE

Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.
The ED₅₀ for this effect is typically 0.4-3 µg/mL in the presence of 10 ng/mL recombinant Activin A.