Human DOT1L/KMT4 recombinant protein
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Protein short names
AW907654; DKFZP586P1823; MDOT1; DOT1; KMT4; DOT1L; KIAA1814; A630076O07
DOT1L; KIAA1814; KMT4
A DNA sequence encoding the human DOT1L (NP_115871.1) N-terminal segment (Gly 2-Lys 416) was expressed and purified, with two additional amino acids (Gly & Pro) at the N-terminus.
The recombinant human DOT1L comprises 417 amino acids and has a predicted molecular mass of 47.6 kDa. It migrates as an approximately 50 kDa band in SDS-PAGE under reducing conditions as predicted.
> 90 % as determined by SDS-PAGE
Human DOT1L / KMT4 Protein SDS-PAGE
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