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  • Human Complement Factor H (His Tag) recombinant protein

Human Complement Factor H (His Tag) recombinant protein

Cat.#: 502186

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Product Information

  • Product Name
    Human Complement Factor H (His Tag) recombinant protein
  • Documents
  • Description
    Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin.
  • Protein name
    HCG40889, isoform CRA_b
  • Protein short names
    COMPLEMENT FACTOR H; HF2; HUS; MGC88246; MUD-1; RP1-177P10.1; FH; CFH; HF; AMBP1; ARMS1; CFHL3; HF1; FHL1; NOM; SAS1; SAS-1; AHUS1; ARMD4
  • Uniprot ID
    P08603
  • Gene Name
    hCG_40889
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the C-terminal segment of CFH isoform a (NP_000177.2), corresponding to amino acid (Ser 860-Arg 1231) was expressed, fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CFH consists of 383 amino acids and has a calculated molecular mass of 43 kDa. The apparent molecular mass of rh CFH is approximately 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to bind biotinylated human DMP1 in a functional ELISA.
  • Validations

    Human Complement Factor H / CFH Protein (His Tag) SDS-PAGE

    Human Complement Factor H / CFH Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"