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Product Name
Mouse GFRA1 (His Tag) recombinant protein
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Description
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).
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Protein name
GDNF family receptor alpha-1
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Protein short names
GDNFR; GDNFRA; TRNR1; FLJ31546; GFR-ALPHA-1; FLJ10561; DKFZP686J0156; RET1L; MGC23045; AU042498; RETL1; DKFZP313E1012; GFRA1
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Uniprot ID
P97785
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Gene Name
Gfra1; Gdnfra; Trnr1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Ser 425) of mouse GFR?1 isoform beta (AAB86600.1) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse GFR?1consists of 412 amino acids and has a calculated molecular mass of 46.3 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 55-60 kDa protein in SDS-PAGE under reducing conditions.
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Purity
> 98 % as determined by SDS-PAGE
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Activity
1. Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells.
The ED50 for this effect is typically 0.3-1.5 μg/mL in the presence of 40 ng/mL Recombinant Human GDNF.
2. Measured by its ability to bind with human GDNF (Cat:500168) in a functional ELISA. -
Validations
Mouse GFRA1 / GFR alpha-1 Protein (His Tag) SDS-PAGE
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